Herbal Extract Artesunate Pharmaceutical Artesunate Powder Artesunate
Product Description
Product Datails
| Product name |
Artesunate |
| Cas number |
88495-63-0 |
| Apperance |
White crystal powder |
| Density |
1.31 |
| MF |
C19H28O8 |
| Refractive index |
1.543 |
Artesunate is used primarily as treatment for malaria; it has also been shown to be >90% efficacious at reducing egg production in Schistosoma haematobium infection. According to WHO intravenous AS is the drug of choice for severe malaria both in children and adults where there is low transmission.In regions where transmission is high, randomized trials among Asian adults and African children strongly advocates the use of artesunate over quinine as the treatment of choice for falciparum malaria. Artesunate is prepared from dihydroartemisinin (DHA) by reacting it with succinic acid anhydride in basic medium. As base/solvent, sodium bicarbonate and catalyst DMAP have been used, with yields of up to 100%. A large scale process involves treatment of DHA with a mixture, a catalytic amount of DMAP and succinic anhydride. The mixture is stirred for 6-9 h to get artesunate in quantitative yield. The product is further re-crystallized. alpha-Artesunate is exclusively formed (m.p 135-137C).
Application&Function
1. With function of controlling of vivax malaria and falciparum malaria symptom, as well as treatment of chloroquine-resistant strain of insect.
2. With function of oxidant. artemisinin is reduced by catalase,dithiothreitol and alpha tocopherol.
3. With the function of antibacterial, artemisinin has anti-influenza virus effect.
4. With the function of anti-parasite, artemisinin on the role of anti-schistosomiasis and leptospirosis.
Specification
Audited Supplier 
){kind=link}
){kind=link}