API CAS 93479-97-1 Glimepiride Pharmaceutical Intermediate Glimepiride Tablet Powder Glimepiride
Product Description
Product Details
| Product Name |
Glimepiride |
| CAS No. |
93479-97-1 |
| MF |
C24H34N4O5S |
| MW |
490.61556 |
| Appearance and shape |
White fine Powder |
Glimepiride is a third-generation sulfonylureas long-acting anti-diabetes drug. The main mechanism of its hypoglycemic effect is to stimulate the secretion of by beta cells of the pancreas and partially increase the sensitivity of surrounding tissues. This product binds to receptor and dissociates faster than glyburide, and causes less severe hypoglycemia. Its mechanism is through and sulfonyl urea receptors on the surface of the pancreatic beta cells (relative molecular mass of 6.5 x 104 protein), the receptor and ATP sensitive K + (KATP) channel phase coupling, pushing the KATP channel close, cause cell membrane depolarization, makes the open voltage dependent calcium channel, Ga2 + internal flow and lead to the release, and inhibit the synthesis of liver glucose. Recent studies have shown that different sulfonylurea coal drugs have different affinities with KATP. The following order: Glenn beauty urea > tolbutamide > sulfonyl chloride propyl urea. In addition, it could be a glucose transporter factor 1, 4 caused by two kinds of protein expression is increased. Due to Glenn beauty of urea to cardiovascular KATP channels in the weaker than Glenn wave urea, gliclazide pass column pyrazine. So cardiovascular adverse reactions are also rare.
Application & Function
Glimepiride is a medium- to long-acting sulfonylureaantidiabetic drug. Glimepiride (Glimer) is indicated to treat type 2 diabetes mellitus; its mode of action is to increase in'sulin production by the pancreas. It is not used for type 1 diabetes because in type 1 diabetes the pancreas is not able to produce in'sulin. Its use is contraindicated in patients with hypersensitivity to glimepiride or other sulfonylureas, and during pregnancy.
Specification
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