| Powder: | Yes |
|---|---|
| Customized: | Customized |
| Certification: | GMP, HSE, ISO 9001, USP, BP |
| Suitable for: | Elderly, Adult |
| State: | Powder |
| Purity: | >99% |
| Samples: |
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| Customization: |
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| Product name | Ursolic Acid |
| Cas number | 77-52-1 |
| Appearance | White powder |
| Melting point | 283-285 C |
| MF | C30H48O3 |
| MW | 456.70032 |
| Density | 1.09 |
Ursolic acid is a kind of triterpenoid compound existing in natural plants, which has various biological effects such as sedation, anti-inflammatory, antibacterial, anti-diabetes, anti-ulcer and lowering blood sugar. Ursolic acid also has obvious antioxidant Chemicalbook function. In addition, ursolic acid can inhibit cell cycle process and cell proliferation by inducing cell apoptosis. Inhibit metastasis and demonstrate anticancer activity by reducing tumorigenesis through multiple signaling pathways.
Current experimental studies have shown that ursolic acid inhibits a variety of cancers, including bladder, colon, breast, cervical, gastric, glioma, neuroblastoma, fibrosarcoma, liver, leukemia, multiple myeloma, lung, ovarian, pancreatic, thyroid, melanoma, and prostate cancer. In order to further understand and investigate the role of ursolic acid in cancer and open up a new chapter of chemotherapy, scientists have conducted a variety of in vitro and in vivo studies. Ursolic acid is also resistant to a variety of carcinogenic and carcinogenic agents. Studies have found that ursolic acid can significantly inhibit the proliferation of HL-60 cells and induce their apoptosis. It can significantly improve the phagocytic function of mouse macrophages, inhibit the proliferation of human tongue squamous cell line TSCCa cells, and inhibit half of the growth of TSCCa cells at a dose of about 12.5Umol•L-1, showing a dose-effect relationship within 24h. In situ hybridization showed that the inhibitory effect of ursolic acid on TSCCa cells was related to the inhibition of in situ expression of nuclear transcription factors. In vivo experiments show that ursolic acid can significantly enhance immune function. Ursolic acid has a wide range of antitumor effects and is likely to be a new type of anticancer drug with low toxicity. Ursolic acid can prevent and inhibit tumor formation and growth and induce cancer cell differentiation. LiJ et al. proved through experiments and clinical trials that ursolic acid could resist DNA mutation and inhibit the initiation of carcinogenic Chemicalbook, and ursolic acid could resist gene mutation induced by carcinogens such as benzopyrene and aflatoxin Bl. Wang Peng test screened the inhibitors of skin cancer promoters by early antibody (EBV-EA) activation test, and found that ursolic acid had almost the same inhibitory effect on TPA-induced EBV-EA activation in Raji cells as tretinoin, and increased the survival rate of Raji cells. The use of isotopically labeled Foster-ester compound 3H-PDB2 demonstrated that ursolic acid did not affect the binding of TPA to the receptor, not by competing for TPA sites, but effectively blocking the link after the binding of the carcinogen to the receptor. Guevara et al. showed that ursolic acid could reduce the number of micronucleated red cells in mutagen-induced polychromatin by 76%. Ohigachi et al. showed that ursolic acid inhibited the EBA-EA activation of Raji cells induced by TPA to the same extent as retinoic acid, and the survival rate of Raji cells was higher than that of retinoic acid treated group. The mechanism was to effectively block the link between TPA and the receptor. Hng et al. found that ursolic acid could significantly inhibit the carcinogenic effect of TPA on skin cancer induced by dimethylbenzoanthracene (DMBA) in mice. The mechanism was that TPA could induce enhanced activity of epidermal ornithine decarcarboxylase (ODC), and ursolic acid could inhibit the above links, thus causing polyamine depletion, growth inhibition, cell accumulation in early stage, and differentiation.
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