Anticancer CAS 183133-96-2 Cabazitaxel API Cabazitaxel Powder Cabazitaxel

• Powder: Yes
• Customized: Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Adult
• State: Powder
• Purity: >99%
• Model NO.: D-sung Cabazitaxel
• Product Name: Cabazitaxel
• Name: Cabazitaxel Powder
• Appearance: White Powder
• Color: White
• Grade: Pharmaceutical Grade
• Assay: HPLC 99%
• Application: Pharmaceutical
• Specific: COA
• Test Method: HPLC
• Shelf Life: 2 Years
• CAS No.: 183133-96-2
• Mf: C45h57no14
• Density: 1.31
• Refractive Index: 1.592
• Melting Point: 180 C
• Transport Package: Negotiable
• Specification: 99%
• Trademark: D-sung
• Origin: Shaanxi Xi′an
• Production Capacity: 1000kg/Month

Product Description

Anticancer CAS 183133-96-2 Cabazitaxel API Cabazitaxel Powder Cabazitaxel

Product Description

Product Details

 

Product Name	Cabazitaxel
CAS	183133-96-2
Appearance	White crystalline powder
MF	C45H57NO14
MW	835.944
Purity	99%
Shelf Life	2 Years

Cabazitaxel was developed by Sanofi-Aventis as an intravenous injectable drug for the treatment of hormone-refractory metastatic prostate cancer. As a microtubule inhibitor, cabazitaxel differs from docetaxel because it exhibits a much weaker affinity for P-glycoprotein (P-gp), an adenosine triphosphate (ATP)-dependent drug efflux pump. Cancer cells that express P-gp become resistant to taxanes, and the effectiveness of docetaxel can be limited by its high substrate affinity for P-gp. Clinical studies confirmed that cabazitaxel retains activity in docetaxel-resistant tumors. Common adverse events with cabazitaxel include diarrhea and neutropenia. Cabazitaxel in combination with predni sone is an important new treatment option for men with docetaxel-refractory metastatic CRPC (castration-resistant prostate cancer).

Application&Function

Cabazitaxel in combination is a treatment option for hormone-refractory prostate cancer following docetaxel-based treatment.
Cabazitaxel anticancer mechanism and characteristics similar with docetaxel, belongs to anti-microtubule drugs. Cabazitaxel through binding to tubulin, promoting their assembly into microtubules, and can prevent these have assembled a microtubule disintegration of the stabilization of microtubules, thereby inhibiting cell mitosis, and interphase cellular functions (interphasecellularfunctions) of play.
1.Cabazitaxel anticancer mechanism and characteristics similar with docetaxel, belongs to anti-microtubule drugs.
2.Cabazitaxel through binding to tubulin, promoting their assembly into microtubules.
3.It can prevent these have assembled a microtubule disintegration of the stabilization of microtubules, thereby inhibiting cell mitosis, and interphase cellular functions (interphasecellularfunctions) of play.

Specification