API Cilastatin Sodium Raw Material Cilastatin Powder Cilastatin Sodium

• Varieties: General Disease Prevention Medicine
• Component: Cilastatin Sodium
• Type: The First Class
• Pharmacodynamic Influential Factors: Animal Species
• Storage Method: Normal
• Product Name: Cilastatin Sodium
• Model NO.: D-sung Cilastatin Sodium
• Name: Cilastatin Sodium Powder
• Appearance: White Powder
• Color: White
• Grade: Pharmaceutical Grade
• Assay: HPLC 99%
• Application: Pharmaceutical
• Specific: COA
• Test Method: HPLC
• Shelf Life: 2 Years
• CAS No.: 81129-83-1
• Mf: C16h25n2nao5s
• Storage Tempera: 0-6c
• Melting Point: 158-161
• Boiling Point: 655.5
• Transport Package: Negotiable
• Specification: 99%
• Trademark: D-sung
• Origin: Shaanxi Xi′an
• Production Capacity: 5000kg/Month

Product Description

API Cilastatin Sodium Raw Material Cilastatin Powder Cilastatin Sodium

Product Description

Product Details

 

 

Product Name	Cilastatin sodium
Appearance	White powder
Purity	99%min by HPLC
CAS No. 81129-83-1	81129-83-1

Cilastatin has antibacterial effects on Gram-positive and negative aerobic and anaerobes. The antibacterial spectrum includes Streptococcus, Staphylococcus aureus, Escherichia coli, Klebsiella, some strains of Acinetobacter, Haemophilus bacillus, Proteus, Serratia, Pseudomonas aeruginosa, etc. Clinically, it is mainly used for respiratory tract infections, biliary tract infections, urinary system and abdominal cavity infections, skin and soft tissues, bones and joints, gynecological infections caused by gram-positive bacteria, negative bacteria, and anaerobic bacteria.

 

The monosodium salt of cilastatin. It is an inhibitor of dehydropeptidase I (membrane dipeptidase, 3.4.13.19), an enzyme found in the brush border of renal tubes and responsible for degrading the antibiotic imipenem. Cilastatin sodium is therefore administ red with imipenem to prolong the antibacterial effect of the latter by preventing its renal metabolism to microbiologically inactive and potentially nephrotoxic products.
Biological ActivityDipeptidase inhibitor (LTDase, leukotriene D4 hydrolase, dehydropeptidase I) that displays a K i value of 0.11 μ M. Inhibits metabolism of LTD 4 to LTE 4 and the hydrolysis of β -lactam antibiotics. Nephroprotective; reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells.

Specification