Pharmaceutical Raw Powder Clotrimazole Material Clotrimazole Purity Clotrimazole

• Powder: Yes
• Customized: Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Powder
• Purity: >99%
• Model NO.: Dsung-Clotrimazole
• Product Name: Clotrimazole
• Name: Clotrimazole Powder
• Appearance: White Crystalline Powder
• Color: White Color
• Test Method: HPLC
• Assay: HPLC 99%
• Specific: COA
• Application: Pharmaceutical Intermediate
• Grade: Pharmaceutical Grade
• Shelf Life: 2 Years
• CAS: 23593-75-1
• Mf: C22h17cln2
• MW: 344.837
• Density: 1.13G/Cm3
• Flash Point: 245.5 C
• Transport Package: Negotiable
• Specification: HPLC99%
• Trademark: D-Sung
• Origin: Shaanxi
• Production Capacity: 3 Ton/Month

Product Description

Pharmaceutical Raw Powder Clotrimazole Material Clotrimazole Purity Clotrimazole

Product Description

Product Details

Product Name	Clotrimazole
CAS No.	23593-75-1
MF	C22H17ClN2
MW	344.83678
Appearance and shape	White crystalline powder

Clotrimazole is an artificially synthetic azo le antifungal agent with inhibitory effect on a variety of pathogenic fungi. It is also able to directly kill the fungi at high concentration. Clotrimazole, through interfering with cytochrome P450 activity, inhibits the biosynthesis of the fungal ergosterol and other steroids; cause damage of the fungal cell membrane and change its permeability, causing the leakage of many kinds of important material in the cell; it can also inhibit the biosynthesis of the fungal triglyceride and phosphor-lipid; the product can still inhibit the activity of oxidase and peroxidase, causing the over-accumulation of peroxides in the cell, causing the degeneration and necrosis of the fungal subcellular structures. Clotrimazole has broad-spectrum antifungal activity with excellent anti-fungal activity against Epidermophyton, Trichophyton, aspergillosis, coloring fungi, Cryptococcus and Candida species. It also has certain antifungal effect against sporothrix schenckii,blastomycosis dermatitidis, Blastomyces coccidioides as well as Histoplasma.

Application & Function

Function
1. Clotrimazole (Lotrimin, Mycelex, etc.) is a synthetic imidazole agent. It acts by altering cell membrane permeability. It inhibits the growth of most dermatophyte species, yeast and Malassezia furfur.
2. Clotrimazole formally also is an imidazole derivative because of the presence of an imidazole ring in its structure. It is believed that, like miconazole, econazole, and other "pure" representatives of the imidazole class, it also inhibits the biosynthesis of ergosterin in the cytoplasmatic membrane of fungi.
3. Clotrimazole is an anti-mycotic, for the treatment of superficial and deep mycotic infections, etc.
Application
Clotrimazole is a broad-spectrum antifungal drug, with good antibacterial effect on a variety of fungi, especially Candida albicans, whose mechanism of action is to inhibit the synthesis of fungal cell membranes and affect their metabolic processes. It has antibacterial effect on superficial fungi and some deep fungi. It is mainly used for external use in the treatment of cutaneous mycoses, such as ringworm, tinea corporis, ear canal and vaginal mycoses. The product is highly toxic, oral administration may have gastrointestinal reactions, liver function abnormalities and leukopenia, etc.. It is now used sparingly. There is no adverse reaction when used externally, and occasionally there is local inflammation. Topical use has 1%-3% cream, suppositories.

Specification