Raw Material Nicergoline Pharmaceutical Chemical Nicergoline Powder Nicergoline

• Powder: Yes
• Customized: Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Powder
• Purity: >99%
• Model NO.: Dsung-Nicergoline
• Product Name: Nicergoline
• Name: Nicergoline Powder
• Appearance: White Powder
• Grade: Pharmaceutical Grade
• Assay: HPLC 99%
• Application: Pharmaceutical Intermediate
• Specific: COA
• Test Method: HPLC
• Shelf Life: 2 Years
• CAS No.: 27848-84-6
• Mf: C24h26brn3o3
• MW: 484.38554
• Density: 1.47
• Melting Point: 134.0 to 138.0 Deg-C
• Boiling Point: 594.4 C at 760 Mmhg
• Transport Package: Negotiable
• Specification: 99%
• Trademark: D-Sung
• Origin: Shaanxi
• Production Capacity: 1 Ton/Month

Product Description

Raw Material Nicergoline Pharmaceutical Chemical Nicergoline Powder Nicergoline

 

Product Description

Product Details

Product Name	Nicergoline
CAS No.	27848-84-6
MF	C24H26BrN3O3
MW	484.38554
Appearance and shape	White powder

Nicergoline is an ergot derivative used to treat senile dementia and other disorders with vascular origins.Target: Alpha-1A adrenergic receptorNicergoline acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines, resulting in peripheral vasodilation. Nicergoline displaced [3H]-prazosin bound to rat forebrain membranes pretreated with chloroethylclonidine (pKi = 9.9 +/- 0.2) at concentrations 60-fold lower than in rat liver membranes (pKi = 8.1 +/- 0.2). Finally, of the nicergoline metabolites studied, lumilysergol acted as a modest alpha 1 antagonist (bromonicotinic acid was devoid of alpha 1 antagonist activity). In conclusion, nicergoline is a potent and selective alpha 1A-adrenoceptor subtype antagonist, an alpha 1-adrenoceptor subtype which is mainly represented in resistance arteries.

Application & Function

1.Nicergoline is an ergot derivative used to treat senile dementia and other disorders with vascular origins. Nicergoline decreases vascular resistance and increases arterial blood flow in the brain,improving the utilization of oxygen and glucose by brain cells. 
2.Nicergoline has similar vasoactive properties in other areas of the body, particularly the lungs.
3.Nicergoline is used for vascular disorders such as cerebral thrombosis and atherosclerosis,arterial blockages in the limbs,Raynaud's disease,vascular migraines,and retinopathy.
4.Nicergoline has been registered in over fifty countries and has been used for more than three decades for the treatment of cognitive, affective,and behavioral disorders of older people.

Specification