Antihypertensive Manidipine Hydrochloride API Manidipine HCl Powder Purity Manidipine Hydrochloride

• Powder: Yes
• Customized: Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Adult
• State: Powder
• Purity: >99%
• Model NO.: D-sung Manidipine Hydrochloride
• Product Name: Manidipine Hydrochloride
• Name: Manidipine HCl
• Appearance: White Powder
• Color: White
• Grade: Pharmaceutical Grade
• Assay: HPLC 99%
• Application: Pharmaceutical;Antihyperation;Antihypertensive
• Specific: COA
• Test Method: HPLC
• Shelf Life: 2 Years
• CAS No.: 89226-75-5
• Mf: C35h40cl2n4o6
• MW: 683.627
• Melting Point: 228-235°c
• Boiling Point: 722 °c at 760 Mmhg
• Transport Package: Negotiable
• Specification: 99%
• Trademark: D-sung
• Origin: Shaanxi Xi′an
• Production Capacity: 500kg/Month

Product Description

Antihypertensive Manidipine Hydrochloride API Manidipine HCL Powder Purity Manidipine Hydrochloride

Product Description

Product Details

Product name	Manidipine Hydrochloride
Cas number	89226-75-5
Appearance	White powder
MF	C35H40Cl2N4O6
MW	683.627

Manidipine Dihydrochloride is a metabolite of Manidipine (M16400), a dihydropyridine calcium channel blocker that exhibits antihypertensive properties. Manidipine 2Hcl (CV-4093) is a dihydropyridine compound and a calcium channel blocker for Ca2+ current with IC50 of 2.6 nM. IC50 value: 2.6 nMTarget: calcium channelManidipine is described to block T-type Ca2+ channels specifically and is also described to have a high selectivity for the vasculature, presenting negligible cardiodepression as compared to other Ca2+ channel antagonists. Manidipine is also described to not significantly affect norepinephrine levels, suggesting a lack of sympathetic activation with this compound. Manidipine reduces pro-inflammatory cytokines secretion in human endothelial cells and macrophages. Manidipine, unlike other third-generation dihydropyridine derived drugs, blocks T-type calcium channels present in the efferent glomerular arterioles, reducing intraglomerular pressure and microalbuminuria.

Application&Function

Manidipine dihydrochloride is a dihydropyridine compound and calcium channel protein inhibitor and antagonist. Manidipine is described to block T-type Ca2+ channels specifically and is also described to have a high selectivity for the vasculature,presenting negligible cardiodepression as compared to other Ca2+ channel antagonists. Manidipine is also described to not significantly affect norepinephrine levels, suggesting a lack of sympathetic activation with this compound.

Specification