99% Purity Phenformin CAS 114-86-3 Phenformin Powder Raw Powder Phenformin

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: D-sung-Phenformin
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Solid
• Purity: >99%
• Product Name: Phenformin
• Name: Phenformin Powder
• Appearance: White Powder
• Color: White Color
• Grade: Pharm Grade
• Assay: HPLC 99%
• Application: Medicine Grade
• Specific: COA
• Test Method: HPLC UV
• COA: 1195-99-9
• Mf: C10h11n
• MW: 145.2
• Hc: 2926909090
• Boiling Point: 62-64 °c
• Density: 1.0541
• Transport Package: Negotiable
• Specification: 99%
• Trademark: D-sung
• Origin: Shaanxi China
• Production Capacity: 5000kg/Month

Product Description

99% Purity Phenformin CAS 114-86-3 Phenformin Powder Raw powder Phenformin

Product Description

Product Datails

Product name	Phenformin
CAS	114-86-3
MF	C10H15N5
MW	205.26
Melting point	176.5 °C
Boiling point	333.94°C

Phenformin, a biguanide with oral hypoglycaemic activity, was introduced in 1957 for the management of diabetes mellitus. By 1970 its use had been associated with incidences of lactic acidosis and by 1976 clinical studies had conclusively demonstrated that the hazards of phenformin treatment outweighed the benefits. Preparations containing phenformin were withdrawn in several countries and their use restricted in others. Elsewhere, however, proprietary preparations containing this drug may remain available. The related biguanide, buformin, has been also associated with lactic acidosis and has been subjected to similar restrictions as phenformin, whereas there is some evidence that metformin is less liable to induce lactic acidosis.

Application&Function

Phenformin hydrochloride increases the sensitivity of surrounding tissues to  and increases mediated glucose utilization.
Phenformin hydrochloride increases the utilization of glucose by non--dependent tissues, such as brain, blood cells, renal medulla, intestines, skin, etc.
Phenformin hydrochloride inhibits liver gluconeogenesis and reduces liver glycogen output.
Phenformin hydrochloride inhibits glucose uptake by intestinal wall cells.
Phenformin hydrochloride inhibits the biosynthesis and storage of cholesterol, and reduces blood triglycerides and total cholesterol levels. Unlike, this product has no effect on promoting fat synthesis, and has no obvious blood sugar lowering effect on normal people. Generally, it does not cause hypoglycemia when used alone for type 2 diabetes.
Phenformin hydrochloride is a hydrochloride salt of phenformin from the biguanide drug class that displays anti-diabetic activity. It has been shown to increase AM.PK activity without increasing AMP/ATP activity. A particular study has shown that treating hearts with phenformin hydrochloride and then perfusing with Krebs-Henseleit buffer increased AMP and AM.PK activity and elevated phosphorylated acetyl-CoA carboxylase. Phenformin hydrochloride increases phosphorylation and AM.PK activity in the isolated heart, and this increase has always been correlated with and preceded by increased cytosolic .

Specification