• 99% Material Crizotinib API Crizotinib Intermediate Powder Crizotinib
  • 99% Material Crizotinib API Crizotinib Intermediate Powder Crizotinib
  • 99% Material Crizotinib API Crizotinib Intermediate Powder Crizotinib
  • 99% Material Crizotinib API Crizotinib Intermediate Powder Crizotinib
  • 99% Material Crizotinib API Crizotinib Intermediate Powder Crizotinib
  • 99% Material Crizotinib API Crizotinib Intermediate Powder Crizotinib

99% Material Crizotinib API Crizotinib Intermediate Powder Crizotinib

Powder: Yes
Customized: Customized
Certification: GMP, HSE, ISO 9001, USP, BP
Suitable for: Elderly, Children, Adult
State: Powder
Purity: >99%
Samples:
US$ 15/g 1 g(Min.Order)
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Customization:
Diamond Member Since 2021

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  • Overview
  • Product Description
  • Product Details
  • Application & Function
  • Specification
Overview

Basic Info.

Model NO.
Dsung-Crizotinib
Product Name
Crizotinib
Name
Crizotinib Powder
Appearance
White to off White Crystalline Powder
Grade
Pharmaceutical Grade
Assay
HPLC 99%
Application
Anti Cancer
Specific
COA
Test Method
HPLC
Shelf Life
2 Years
CAS No.
877399-52-5
Molecular Formula
C21h22cl2fn5o
MW
450.33700
Boiling Point
599.177 C at 760 Mmhg
Density
1.475g/cm3
Refractive Index
1.673
Transport Package
Negotiable
Specification
99%
Trademark
D-Sung
Origin
Shaanxi
Production Capacity
10kg/Month

Product Description

99% Material Crizotinib API Crizotinib Intermediate Powder Crizotinib
99% Material Crizotinib API Crizotinib Intermediate Powder Crizotinib
 
Product Description

99% Material Crizotinib API Crizotinib Intermediate Powder Crizotinib99% Material Crizotinib API Crizotinib Intermediate Powder Crizotinib

Product Details

99% Material Crizotinib API Crizotinib Intermediate Powder Crizotinib

Product Name Crizotinib
CAS No. 877399-52-5
Purity 99%
MW 450.33700
Appearance and shape White to off white crystalline powder
Crizotinib is an anti-cancer drug acting as an ALK (anaplastic lymphoma kinase) and ROS1 (c-ros oncogene 1) inhibitor, approved for treatment of some non-small cell lung carcinoma (NSCLC) in the US and some other countries, and undergoing clinical trials testing its safety and efficacy inanaplastic large cell lymphoma, neuroblastoma, and other advanced solid tumors in both adults and children.
Application & Function

99% Material Crizotinib API Crizotinib Intermediate Powder CrizotinibFunction
Crizotinib has an aminopyridine structure, and functions as a protein kinase inhibitor by competitive binding within the ATP-binding pocket of target kinases. About 4% of patients with non-small cell lung carcinoma have a chromosomal rearrangement that generates a fusion genebetween EML4 ('echinoderm microtubule-associated protein-like 4') andALK ('anaplastic lymphoma kinase'), which results in constitutivekinase activity that contributes to carcinogenesis and seems to drive the malignant phenotype. The kinase activity of the fusion protein is inhibited by crizotinib. Patients with this gene fusion are typically younger non-smokers who do not have mutations in either theepidermal growth factor receptor gene (EGFR) or in the K-Ras gene.The number of new cases of ALK-fusion NSLC is about 9,000 per year in the U.S. and about 45,000 worldwide
Application
1.Treating certain types of lung cancer. It may also be used for other conditions as determined by your doctor.
2.Crizotinib is a tyrosine kinase inhibitor. It works by preventing the growth of cancer cells.
3.Crizotinib inhibits the c-Met/Hepatocyte growth factor receptor (HGFR) tyrosine kinase, which is involved in the oncogenesis of a number of other histological forms of malignant neoplasms.
4.Crizotinib is currently thought to exert its effects through modulation of the growth, migration, and invasion of malignant cells.Other studies suggest that crizotinib might also act via inhibition of angiogenesis in malignant tumors.

Specification

99% Material Crizotinib API Crizotinib Intermediate Powder Crizotinib99% Material Crizotinib API Crizotinib Intermediate Powder Crizotinib99% Material Crizotinib API Crizotinib Intermediate Powder Crizotinib99% Material Crizotinib API Crizotinib Intermediate Powder Crizotinib99% Material Crizotinib API Crizotinib Intermediate Powder Crizotinib99% Material Crizotinib API Crizotinib Intermediate Powder Crizotinib99% Material Crizotinib API Crizotinib Intermediate Powder Crizotinib

 

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Management System Certification
ISO 9001, ISO 14001, GMP, HACCP