API Nateglinide powder Antidiabetic Nateglinide powder Raw Material Nateglinide
Product Description
Product Datails
| Product Name |
Nateglinide |
| CAS: |
105816-04-4 |
| MF |
C19H27NO3 |
| Molecular Wegiht:317.42 |
262-145-8 |
Nateglinide is an oral antihyperglycemic agent used for the treatment of non Diabetes drug API Nateglinide/trans-d-phenylalanine CAS 105816-04-4dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting secretagogues, which act by binding to β cells of the pancreas to stimulate release. Nateglinide is an amino acid derivative that induces an early response to meals decreasing postprandial blood glucose levels. It should only be taken with meals and meal-time doses should be skipped with any skipped meal. Approximately one month of therapy is required before a decrease in fasting blood glucose is seen. Meglitnides may have a neutral effect on weight or cause a slight increase in weight. The average weight gain caused by meglitinides appears to be lower than that caused by sulfonylureas and and appears to occur only in those naïve to oral antidiabetic agents. Due to their mechanism of action, meglitinides may cause hypoglycemia although the risk is thought to be lower than that of sulfonylureas since their action is dependent on the presence of glucose. In addition to reducing postprandial and fasting blood glucose, meglitnides have been shown to decrease glycosylated hemoglobin (HbA1c) levels, which are reflective of the last 8-10 weeks of glucose control. Meglitinides appear to be more effective at lowering postprandial blood glucose than metformin, sulfonylureas and thiazolidinediones. Nateglinide is extensively metabolized in the liver and excreted in urine (83%) and feces (10%). The major metabolites possess less activity than the parent compound. One minor metabolite, the isoprene, has the same potency as its parent compound.
Application&Function
1. Nateglinide is used for the treatment of the form of diabetes mellitus that appears most frequently in adulthood -- known as type 2 or non-insulin-dependent diabetes -- that cannot be managed by exercise and control of diet alone.
2. Nateglinide may be added to diet and exercise to manage the disease, or it may be combined with metformin when diet, exercise, and either drug alone cannot provide adequate control of blood sugar.
Specification
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