Customization: | Available |
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Powder: | Yes |
Customized: | Customized |
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Product Name | Erythromycin |
Appearance | White Powder |
CAS No. | 114-07-8 |
MF | C37H67NO13 |
MW | 733.93 |
Erythromycin is a motilin receptor agonist, and the spatial structure of the 14 membered lactone ring on the glycosidic chain of erythromycin molecule is similar to that of motilin. It can act as a motilin receptor agonist, producing a simulated motilin effect and inducing premature phase III contraction of MMC in fasting state, causing smooth muscle contraction in the stomach and duodenum. The gastric motility promoting effect of erythromycin is dose dependent. Low doses of erythromycin induce gastric contractions similar to spontaneous MMC, while high doses of erythromycin cause strong irregular gastric and duodenal contractions leading to vomiting, which is also the reason why erythromycin causes gastrointestinal reactions. Therefore, the dosage of erythromycin for promoting gastric motility should not be too high. The commonly used macrolide antibiotics have an antibacterial spectrum similar to penicillin, mainly used for patients allergic to penicillin or for infections caused by penicillin resistant Staphylococcus aureus. They can also be used for infections caused by streptococcus, pneumococcus, and diphtheria carriers.
purpose
Erythromycin can treat digestive system diseases, and EM has varying degrees of prokinetic effects on the entire gastrointestinal tract. There are mainly the following effects: promoting esophageal contraction and increasing lower esophageal sphincter pressure (LESP); Promote gastric antrum contraction and improve the coordination of gastric antrum and duodenal function; Inducing gastrointestinal migration complex movement; Promote colon movement and gallbladder contraction. Therefore, it can effectively treat gastrointestinal diseases.