99% purity Flupirtine Material CAS 75507-68-5 Flupirtine Material powder Flupirtine Material
Product Description
Product Details
| Product Name |
Flupirtine Material |
| CAS NO. |
75507-68-5 |
| Purity |
99% |
| MF |
C19H21FN4O6 |
| MW |
420.3916 |
Application&Function
Function
Flupirtine maleate is a novel analgesic whose mechanism of action is a selective neurogenic potassium channel opener with triple effects of analgesia, muscle relaxation and neuroprotection. It is mainly used for the treatment of various types of moderate acute pain, such as pain caused by surgery, trauma, etc., as well as headache/migraine and abdominal cramps.
Application
1 It has analgesic effect and selectively opens the voltage-independent K+ channel of nerve cells. k+ outflow. The static potential tends to be stable, and the neurons are not easily excited. This indirect antagonist of NMDA receptors. The influx of ca2+ is reduced, and the sensitive effect caused by the increase of intracellular Ca2+ concentration is buffered. In this way, the conduction of nociceptive pain impulses is inhibited in the excited state of neurons.
2 Muscle relaxant at therapeutic concentrations. The uptake of Ca2+ by mitochondria enhanced the above-mentioned analgesic effect. This may be related to the muscle relaxation effect caused by the inhibition of nerve impulse conduction of motor neurons and interneurons. But this muscle relaxant effect is a decrease in muscle tone.
3 Influence on pain persistence, pain persistence is actually a nerve conduction disease caused by the remodeling of neurons. Intracellular lesions induce remodeling of neuronal function. The response to subsequent impulses is enhanced by the so-called -wind-up-mechanism. NMDA receptors have special significance for triggering this change (gene expression). Indirect blockade of NMDA receptors by flupirtine maleate is an inhibitory effect that counteracts persistent pain. If the pain has persisted. Then the stabilization of the cell membrane potential will gradually eliminate pain memory and reduce pain sensitivity.
Toxicology study
Specification
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99% purity Flupirtine Material CAS 75507-68-5 Flupirtine Material powder Flupirtine Material
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