Tripterygium Extract Celastrol Powder Pharmaceutical Celastrol

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: D-sung Celastrol
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Powder
• Purity: >99%
• Product Name: Celastrol
• Name: Celastrol Powder
• Appearance: Red Powder
• Color: Red
• Grade: Pharmaceutical Grade
• Assay: HPLC 99%
• Application: Pharmaceutical
• Specific: COA
• Test Method: HPLC
• CAS No.: 34157-83-0
• Mf: C29h38o4
• MW: 450.61
• Density: 1.2
• Melting Point: 219-230
• Boiling Point: 645.7
• Transport Package: Negotiable
• Specification: 99%
• Trademark: D-sung
• Origin: Xi′an Shaanxi
• Production Capacity: 500kg/Month

Product Description

Tripterygium Extract Celastrol Powder Pharmaceutical Celastrol 

Product Description

Product Details

Product Name	Celastrol
Appearance	Red Powder
CAS No.	34157-83-0
MF	C29H38O4
MW	450.61

Tripterygium wilfordii extract, also known as southern snake vine extract, is a natural product with various biological activities. It has strong antioxidant effects, anti-cancer angiogenesis effects, and anti rheumatoid effects. It mainly comes from the root bark of the plant Tripterygium wilfordii in the family Celastraceae. It is one of the effective ingredients in the treatment of rheumatoid diseases such as Tripterygium wilfordii tablets and Tripterygium wilfordii polysaccharide tablets.
Although Thunder God Vine is highly toxic, it can alleviate the "poison of love flowers" after being refined through traditional Chinese medicine methods. In modern medicine, one of the most important active ingredients of Tripterygium wilfordii has been found to be resveratrol, which can be used to treat obesity, chronic inflammation, and immune diseases. In 2007, Triptolide, Artemisinin, Triptolide, Capsaicin, and Curcumin were listed as the five most likely and worthwhile natural compounds to be developed into modern drugs by the journal Cell. Although high-dose celastrol has certain cardiotoxicity, low-dose celastrol has been found to protect the cardiovascular system. Its exact therapeutic effect, underlying mechanisms, and unknown targets have attracted the attention of many scientists.

Application&Function

The main activities and pharmacological effects of Tripterygium wilfordii extract:
1. Cytotoxic activity. Has strong non-specific cytotoxic activity against P388 and a group of human cancer cell lines in vitro.
2. Immune regulatory effect. Significantly inhibit the formation of hemolytic plaque cells in mouse spleen cells. Significantly inhibit delayed hypersensitivity reactions in mice.
3. Anti inflammatory effect. At a dose of 0.5mg/kg, it significantly inhibited the formation of cotton ball granulomas in rats. Inhibition of PGE2 production induced by yeast sugar at 0.1-1.0 μ g/mL; At a concentration of 1.0 μ g/mL, it inhibits the phagocytic activity of macrophages.
4. The anti peroxidation effect of Triptolide is 15 times that of tocopherol, with an IC50 of 7 μ M. Inhibit peroxidation inside and outside the mitochondrial membrane, directly clearing free radicals.
5. Triptolide can prolong the sleep time of mice induced.
6. Immunosuppressive effect: Inhibits mouse spleen cell proliferation induced by PHA, ConA, LPS, etc., and suppresses lymphocyte proliferation.
7. Inhibit the fertilization ability of guinea pig sperm in vitro, with significantly stronger activity than gossypol acetate.
8. Anti arthritis effect. Inhibit the activity of interleukin-1 inside and outside mouse peritoneal macrophages, inhibit the production of interleukin-2 by mouse spleen cells, and reduce the release of PGE2 by rabbit synovial cells.

Specification