Antibacterial Sulfamethoxazole Pharmaceutical Sulfamethoxazole Sulfamethoxazole
Product Description
Product Details
Product Name |
Sulfamethoxazole |
CAS No. |
723-46-6 |
MF |
C10H11N3O3S |
MW |
253.27 |
Appearance and shape |
White crystalline powder |
Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic. Target: AntibacterialSulfonamides are structural analogs and competitive antagonists of para-aminobenzoic acid (PABA). They inhibit normal bacterial utilization of PABA for the synthesis of folic acid, an important metabolite in DNA synthesis. The effects seen are usually bacteriostatic in nature. Folic acid is not synthesized in humans, but is instead a dietary requirement. This allows for the selective toxicity to bacterial cells (or any cell dependent on synthesizing folic acid) over human cells. Bacterial resistance to sulfamethoxazole is caused by mutations in the enzymes involved in folic acid synthesis that prevent the drug from binding to it.
Application & Function
1. It is primarily used in the treatment of urinary tract infections, although it may be used against any susceptible aerobic bacterial species.
2. It may also be used to treat and prevent Pneumocystis jirovecii pneumonia.
3. It is generally not recommended for the treatment of anaerobic infections such as Clostridium difficile colitis (the leading cause of antibiotic-induced diarrhea).
4. Trimethoprim has been used in trials to treat retinitis.
5. Resistance to trimethoprim is increasing, but it is still a first line antibiotic in many countries.
Specification





