| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
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| Product Name | Valnemulin |
| Appearance | White Powder |
| CAS No. | 101312-92-9 |
| MF | C31H52N2O5S |
| MW | 564.82 |
Oral administration of vonimilin to pigs rapidly absorbs, with an absorption rate greater than 90%. The highest plasma concentration is reached 1-4 hours after administration, and the plasma half-life is 1.3-2.7 hours. Oral single dose of 10 mg/kg body weight vonidazole hydrochloride, peak time 1.85 hours, peak concentration 1.29 μ g/ml, area under the curve (AUC) 5.58 μ g/ml/hour. When the dose is 25mg/kg body weight, the peak time is 2.9 hours, the peak concentration is 2.67 μ g/ml, and the area under the curve (AUC) is 18.23 μ g/ml/hour; When the dose is 50mg/kg body weight, the peak time is 4.15 hours, the peak concentration is 6.23 μ g/ml, and the area under the curve (AUC) is 67.3 μ g/ml/hour; There is a linear relationship between plasma concentration and dosage. After repeated administration, slight accumulation occurred, but remained stable within 5 hours. Administer 5 mg/kg body weight twice a day, and maintain a stable plasma concentration for 7.5 days. Due to the obvious first pass effect, plasma concentration is affected by the administration method. But Vanillin is mainly concentrated in tissues, especially in lung and liver tissues. Five days after the last administration of 15 doses of radioactive markers of Warnimilin to pigs, the liver concentration was greater than six times the plasma concentration. 15mg/kg body weight per day, fed twice a day for 4 consecutive weeks. Two hours after discontinuation, the liver concentration was 1.58ug/g and the lung concentration was 0.23ug/g, while the plasma concentration was lower than the detection value.
Wonimaolin 200ppm mixed feeding, with a drug concentration of 5.20ug/ml in the colon contents; 75ppm mixed feeding, with a drug concentration of 1.68ug/ml in the colon contents. The concentration of colonic contents is linearly related to the concentration of mixed feeding.
Vanillin undergoes extensive metabolism and excretion in pigs, with metabolites mainly rapidly excreted through bile and feces. 87% of radioactive markers are excreted within 3 days after the last administration, and approximately 3% are excreted in urine during the same period.
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