Customization: | Available |
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Powder: | Yes |
Customized: | Customized |
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Product Name | Clotrimazole |
Appearance | Write Powder |
CAS No. | 23593-75-1 |
MF | C22h17cln2 |
MW | 344.83678 |
The mechanism of action of clotrimazole
(1) By reducing the activity of cytochrome P450, the biosynthesis of sterols such as ergosterol on the fungal cell membrane is inhibited, damaging the fungal cell membrane and altering its permeability, resulting in the loss of important substances inside the cell.
(2) Clotrimazole can also inhibit the biosynthesis of triglycerides and phospholipids in fungi.
(3) It can inhibit the activity of oxidase and peroxidase, leading to excessive accumulation of in cells, causing fungal subcellular structural degeneration and cell necrosis.
(4) Candida albicans can inhibit its transformation from spores to invasive hyphae.
The use of clotrimazole: a broad-spectrum antifungal drug. Used for systemic fungal infections and also for local fungal infections.