Intermediate Tofacitinib Citrate Manufacturer Supply High Purity 99% API Tofacitinib Citrate

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: D-Sung Tofacitinib Citrate
• Product Name: Tofacitinib Citrate
• Name: Tofacitinib Citrate Powder
• Appearance: White Powder
• Color: White
• Grade: Pharmaceutical Grade
• Assay: HPLC 99%
• Application: Pharmaceutical
• Specific: COA
• Test Method: HPLC
• Shelf Life: 2 Years
• CAS No.: 540737-29-9
• Mf: C16h20n6o.C6h8o7
• MW: 504.497
• Melting Point: 201 C
• Storage Temperature: Room Temp
• Transport Package: Negotiable
• Specification: 99%
• Trademark: D-sung
• Origin: Shaanxi Xi′an
• Production Capacity: 1000kg/Month

Product Description

Intermediate Tofacitinib Citrate Manufacturer Supply High Purity 99% API Tofacitinib Citrate

Product Description

Product Details

Product Name	Esomeprazole Sodium
CAS NO.	161796-78-7
Purity	99%
Boiling Point	600 C at 760 mmHg
Appearance and shape	White powder

Esomeprazole Sodium is the sodium salt of the S-isomer of omeprazole, with gastric proton pump inhibitor activity. In the acidic compartment of parietal cells, esomeprazole is protonated and converted into the active achiral sulfenamide; the active sulfenamide forms one or more covalent disulfide bonds with the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting its activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production. H+/K+ ATPase is an integral membrane protein of the gastric parietal cell.

Application&Function

Tofacitinib works by inhibiting Janus kinases, enzymes that play a role in the signaling pathways of various inflammatory cytokines. By blocking these pathways, tofacitinib helps reduce inflammation and modulate immune responses in autoimmune conditions.
Indications: Tofacitinib citrate is approved for the treatment of several conditions, including:
1.Rheumatoid Arthritis: It is used to manage moderate to severe rheumatoid arthritis in adults who have not responded well to other disease-modifying antirheumatic drugs (DMARDs).
2.Psoriatic Arthritis: Tofacitinib is also indicated for the treatment of active psoriatic arthritis in adults.
3.Ulcerative Colitis: It is used for the treatment of moderate to severe ulcerative colitis in patients who have not responded adequately to other therapies.
4.Dosage and Administration: The dosage of tofacitinib citrate can vary depending on the specific condition being treated. It is typically taken orally, either as tablets or an oral solution. The dosing regimen and any dosage adjustments should be determined by a healthcare provider based on individual patient factors.
Efficacy: Clinical studies have shown that tofacitinib citrate can be effective in reducing the signs and symptoms of rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. It can also help improve physical function and quality of life in patients with these conditions.

Specification