API CAS 112529-15-4 Pioglitazone Raw Diabetes Pioglitazone HCl Powder Pioglitazone Hydrochloride

• Powder: Yes
• Customized: Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Powder
• Purity: >99%
• Model NO.: Dsung-Pioglitazone Hydrochloride
• Product Name: Pioglitazone Hydrochloride
• Name: Pioglitazone Hydrochloride Powder
• Appearance: White Powder
• Grade: Pharmaceutical Grade
• Assay: HPLC 99%
• Application: Diabetes
• Specific: COA
• Test Method: HPLC
• Shelf Life: 2 Years
• CAS No.: 112529-15-4
• Molecular Formula: C19h21cln2o3s
• Melting Point: 193-194 C
• Boiling Point: 575.4 C at 760 Mmhg
• Refractive Index: 1.64
• Density: 1.26 g/cm3
• Transport Package: Negotiable
• Specification: 99%
• Trademark: D-Sung
• Origin: Shaanxi
• Production Capacity: 500kg/Month

Product Description

API CAS 112529-15-4 Pioglitazone Raw Diabetes Pioglitazone Hcl Powder Pioglitazone Hydrochloride

 

Product Description

Product Details

Product Name	Pioglitazone Hydrochloride
CAS NO.	112529-15-4
Purity	99%
Melting point	193-194 C
Appearance and shape	White powder

Pioglitazone is a new orally active thiazolidinedione (TZD) launched in the US for the treatment of  dependent diabetes mellitus (NIDDM). As with other representatives in this class, it potently activates the nuclear receptor peroxisome proliferator-activated receptor gamma which is believed to be involved in the regulation of  resistance and adipogenesis. In several obese and obese diabetic animal models, treatment with Pioglitazone resulted in reductions in plasma glucose and serum lipids. In clinical studies, Pioglitazone at a once daily oral dose of 15-45 mg, as monotherapy or in combination with non-TZDs , was shown to significantly improve glycemic control in type-2 diabetes and demonstrated a beneficial effect on  resistance and other clinically relevant parameters as plasma levels of triglycerides or HDL-cholesterol. Pioglitazone is reported to be safe and well tolerated and is said to have a lower occurrence of hepatic toxicity as well as a low probability for drug interaction.

Application & Function

Pioglitazone Hydrochloride is indicated for type 2 diabetes (non-insulin-dependent diabetes mellitus, NIDDM) patients, pioglitazone hydrochloride can be combined with diet control and physical exercise to improve and control blood sugar. Pioglitazone hydrochloride can be used alone or in combination with sulfonylurea, metformin, or insulin when dietary control, physical exercise, and monotherapy are not satisfactory for glycemic control. Type 2 diabetes management should also include nutritional counseling, necessary weight loss, and physical activity. These efforts are not only important in the initial treatment of type 2 diabetes, but also in drug maintenance therapy.

Specification