| Customization: | Available |
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| Powder: | Yes |
| Customized: | Negotiable |
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| Product Name | Articaine Hydrochloride |
| Appearance | White or almost white powder |
| CAS No. | 23964-57-0 |
| pH | 4.5 - 6.5 |
| Melting Point | 150°C - 154°C |
Articaine hydrochloride (CAS: 23964-57-0) is an amide local anesthetic with a unique chemical structure, characterized by fast onset, strong anesthetic efficacy, and high safety. Its molecular structure contains a ring, which enhances its lipophilicity and makes it easier to penetrate neural membranes to exert its effects. This product usually exists in the form of white crystalline powder, which meets the pharmacopoeia standards (EP/USP) and is suitable for injection anesthesia preparations. Articaine hydrochloride is widely used in dental surgery, minor surgery, and pain management. Due to its rapid metabolism (hydrolyzed by plasma esterase) and low residual risk in the body, it is one of the commonly used short acting local anesthetics in clinical practice.
Articaine hydrochloride reversibly blocks voltage-gated sodium channels on nerve cell membranes, inhibiting action potential generation and conduction, thereby blocking pain signal transmission. Its anesthetic effect is stronger than lidocaine, with an onset time of about 1-3 minutes and a duration of 1-4 hours (prolonged when combined with . Due to its ester bond structure, metabolism does not rely on the liver, but is hydrolyzed by esterases in the blood, reducing the burden on the liver and kidneys, making it suitable for patients with liver function limitation. Mainly suitable for short-term operations such as dental tooth extraction and root canal treatment, with occasional mild adverse reactions (such as transient palpitations or allergic reactions), but overall safety is relatively high.
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