• 99% CAS 149647-78-9 Vorinostat Pharmaceutical Intermediate Vorinostat Powder Purity Vorinostat
  • 99% CAS 149647-78-9 Vorinostat Pharmaceutical Intermediate Vorinostat Powder Purity Vorinostat
  • 99% CAS 149647-78-9 Vorinostat Pharmaceutical Intermediate Vorinostat Powder Purity Vorinostat
  • 99% CAS 149647-78-9 Vorinostat Pharmaceutical Intermediate Vorinostat Powder Purity Vorinostat
  • 99% CAS 149647-78-9 Vorinostat Pharmaceutical Intermediate Vorinostat Powder Purity Vorinostat
  • 99% CAS 149647-78-9 Vorinostat Pharmaceutical Intermediate Vorinostat Powder Purity Vorinostat

99% CAS 149647-78-9 Vorinostat Pharmaceutical Intermediate Vorinostat Powder Purity Vorinostat

Powder: Yes
Customized: Customized
Certification: GMP, HSE, ISO 9001, USP, BP
Suitable for: Elderly, Children, Adult
State: Powder
Purity: >99%
Samples:
US$ 30/g 1 g(Min.Order)
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Customization:
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  • Overview
  • Product Description
  • Product Details
  • Application & Function
  • Specification
Overview

Basic Info.

Model NO.
Dsung-Vorinostat
Product Name
Vorinostat
Name
Vorinostat Powder
Appearance
White Powder
Grade
Pharmaceutical Grade
Assay
HPLC 99%
Application
Antineoplastic
Specific
COA
Test Method
HPLC
Shelf Life
2 Years
CAS No.
149647-78-9
Mf
C14h20n2o3
MW
264.3202
Melting Point
161-162 C
Density
1.174
Refractive Index
1.566
Transport Package
Negotiable
Specification
99%
Trademark
D-Sung
Origin
Shaanxi
Production Capacity
500kg/Month

Product Description

99% CAS 149647-78-9 Vorinostat Pharmaceutical Intermediate Vorinostat Powder Purity Vorinostat
99% CAS 149647-78-9 Vorinostat Pharmaceutical Intermediate Vorinostat Powder Purity Vorinostat
 
Product Description

99% CAS 149647-78-9 Vorinostat Pharmaceutical Intermediate Vorinostat Powder Purity Vorinostat99% CAS 149647-78-9 Vorinostat Pharmaceutical Intermediate Vorinostat Powder Purity Vorinostat

Product Details

99% CAS 149647-78-9 Vorinostat Pharmaceutical Intermediate Vorinostat Powder Purity Vorinostat

Product Name Vorinostat
CAS No. 149647-78-9
MF C14H20N2O3
MW 264.3202
Appearance and shape White Powder
Vorinostat is a group of protein deacetylase (HDAC) inhibitors. It can play a role by inducing cell differentiation, blocking the cell cycle, and inducing cell regulation. Treatment of aggravation, persistence, and recurrence or ineffective cutaneous T-cell lymphoma (CTCL, a non-Hodgkin's lymphoma) after treatment with two systemic drugs. CTCL is a type of T cell carcinoma that affects the white blood cell types of the skin.
Application & Function

99% CAS 149647-78-9 Vorinostat Pharmaceutical Intermediate Vorinostat Powder Purity VorinostatVorinostat is the first drug in a new class of anti-cancer agents that inhibit histone deacetylases (HDAC). It was launched as an oral treatment for cutaneous manifestations in patients with cutaneous T-cell lymphoma (CTCL) who have progressive, persistent, or recurrent disease on or following two systemic therapies. HDACs are enzymes that catalyze the removal of the acetyl modification on lysine residues of proteins, including the core nucleosomal histones. Together with their counterpart histone acetyltransferases (HATs), HDACs regulate the acetylation level of the histones, which plays an important role in the regulation of chromatin plasticity and gene transcription. Hypoacetylation of histones is associated with a condensed chromatin structure resulting in the repression of gene transcription, whereas acetylated histones are associated with a more open chromatin structure and activation of transcription. In some cancer cells, there is an overexpression of HDACs, resulting in hypoacetylation of histones. Inhibitors of HDAC are thought to transcriptionally reactivate dormant tumor-suppressor genes by allowing for the accumulation of acetyl groups on histones and an open chromatin structure. Vorinostat inhibits the enzymatic activity of HDAC1, HDAC2, HDAC3, and HDAC6 at nanomolar concentrations (IC50 <86 nM). In vitro, it induces growth arrest, differentiation or apoptosis in a variety of tumor cells. In addition, vorinostat inhibits tumor growth in animal models bearing solid tumors, including breast, prostate, lung and gastric cancers, as well as hematologic malignancies such as multiple myeloma and leukemias.

Specification

99% CAS 149647-78-9 Vorinostat Pharmaceutical Intermediate Vorinostat Powder Purity Vorinostat99% CAS 149647-78-9 Vorinostat Pharmaceutical Intermediate Vorinostat Powder Purity Vorinostat99% CAS 149647-78-9 Vorinostat Pharmaceutical Intermediate Vorinostat Powder Purity Vorinostat99% CAS 149647-78-9 Vorinostat Pharmaceutical Intermediate Vorinostat Powder Purity Vorinostat99% CAS 149647-78-9 Vorinostat Pharmaceutical Intermediate Vorinostat Powder Purity Vorinostat99% CAS 149647-78-9 Vorinostat Pharmaceutical Intermediate Vorinostat Powder Purity Vorinostat99% CAS 149647-78-9 Vorinostat Pharmaceutical Intermediate Vorinostat Powder Purity Vorinostat

 

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Management System Certification
ISO 9001, ISO 14001, GMP, HACCP