| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
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| Product Name | Hydrochlorothiazide |
| CAS No. | 58-93-5 |
| MF | C7H8ClN3O4S2 |
| MW | 297.73912 |
| Appearance and shape | White crystalline powder |
Function:
1. Sodium-removal diuretic effect: It mainly inhibits the reabsorption of Na+ and Cl- in the anterior segment of the distal tubule and the proximal tubule (lighter effect), resulting in increased urinary sodium, potassium, chloride, phosphorus and magnesium ions excretion, and decreased urinary calcium excretion.
2. Antihypertensive effect: It has a mild but definite hypotensive effect, and can reduce systolic and diastolic blood pressure in the standing and lying positions, and also increase the hypotensive effect of other antihypertensive drugs.
3. Antidiuretic effect: It reduces urine output in nephrogenic uremia, sometimes by up to 50%, the exact mechanism of action is unknown.
Application:
1. Edema disease: including congestive heart failure, cirrhosis, nephrotic syndrome, acute and chronic nephritis edema, chronic renal failure early, adrenocorticotropic hormone and estrogen therapy caused retention of sodium and water.
2. High blood pressure: it can be used alone or in combination with other antihypertensive drugs. It is mainly used for the treatment of essential hypertension.
3. Central or nephrogenic diabetes insipidus.
4. Kidney stone disease: it is mainly used for the prevention of calcium stone formation.
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