Pharmaceutical Entecavir Powder Antiviral Entecavir

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: D-sung Entecavir
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Powder
• Purity: >99%
• Product Name: Entecavir
• Name: Entecavir Powder
• Appearance: White Powder
• Color: White
• Grade: Pharmaceutical Grade
• Assay: HPLC 99%
• Application: Pharmaceutical
• Specific: COA
• Test Method: HPLC
• CAS No.: 142217-69-4
• Mf: C12h15n5o3
• MW: 277.28
• Density: 1.81
• Melting Point: 249-252
• Boiling Point: 661.4
• Transport Package: Negotiable
• Specification: 99%
• Trademark: D-sung
• Origin: Shaanxi Xi′an
• Production Capacity: 500kg/Month

Product Description

Pharmaceutical Entecavir Powder Antiviral Entecavir

Product Description

Product Details

Product Name	Entecavir
Appearance	White Powder
CAS No.	142217-69-4
MF	C12H15N5O3
MW	277.28

Entecavir is a new generation of guanine nucleoside analog oral drug used to treat hepatitis B virus infection. It is mainly used to treat chronic hepatitis B with active virus replication and continuous increase of serum transaminase in adults, or with active liver histology. It is currently the fastest and strongest nucleoside analog with the lowest mutation rate. The data shows that different chronic hepatitis B patients, including those with initial nucleoside treatment, nucleoside treatment and cirrhosis, can quickly control the disease condition through the use of entecavir tablets, and easily reach the real end point of treatment, that is, hepatitis B virus is undetectable; By persisting in treatment, a considerable number of patients can achieve the satisfactory endpoint of treatment, namely e antigen serological conversion, and some patients can even reach the ideal endpoint of treatment, namely surface antigen conversion to negative.

Application&Function

This product is a guanine nucleoside analog, which has an inhibitory effect on hepatitis B virus (HBV) polymerase. It can be phosphorylated into active triphosphate, which has a half-life of 15 hours in cells. By competing with the natural substrate of HBV polymerase, deoxyguanosine triphosphate, entecavir triphosphate can inhibit all three activities of viral polymerase (reverse transcriptase): (1) initiation of HBV polymerase; (2) Formation of reverse transcription negative chains of pre genomic mRNA; (3) Synthesis of HBVDNA positive strand. The inhibition constant (Ki) of entecavir triphosphate on HBV DNA polymerase is 0.0012 μ M. Entecavir triphosphate has weak inhibitory effects on cellular alpha, beta, delta DNA polymerase and mitochondrial gamma DNA polymerase, with Ki values ranging from 18 to 160 μ M.

Specification