Pharma Lappaconitine Hydrobromide Powder Hydrobromide Lappaconitine API Lappaconitine Hydrobromide
Product Description
Product Details
| Product Name |
Lappaconitine hydrobromide |
| CAS No. |
97792-45-5 |
| Purity |
99% |
| MW |
665.61200 |
| Appearance and shape |
White or almost crystalline powder |
Lappaconitine hydrobromide (Lappaconitine) is a diterpene alkaloid isolated from the ranunculaceae plant Lappaconitine -Labaconitine, its chemical name is (1α,14α,16β)-20-B Base-1,14,16Chemicalbook-Trimethoxyaconitine-4,8,9-triol 4-[2-(acetylamino)benzoate hydrobromide monohydrate. It is the first non-addictive analgesic drug in China. It has the effects of analgesia, antipyretic, swelling and local anesthesia, and has no addictive and accumulation effects.
Lappaconitine hydrobromide, a diterpene alkaloid, is a drug for the treatment of cardiac arrhythmias. IC50 value: Target: A natural product for anti-cardiac arrhythmias In vitro: Lappaconitine hydrobromide was found to exert an inhibitory effect on inward tetrodotoxin-sensitive sodium currents without changing their voltage dependence [1]. In vivo: The effect of Lappaconitine hydrobromide on aconitine--induced arrhythmias is due to modulation of genes encoding Na(+)-, K(+)-, Ca(2+)-channels, conducting ionic currents (I(Na), I(to), I(Ks), I(K1), I(CaT)), which are involved in the formation of different phases of the action potential [2]. Lappaconitine hydrobromide was found to be beneficial both in ventricular and supraventricular premature beats. Oral allapinine usually showed its effect 40-60 minutes following its administration, its maximum action being 4-5 hours later, its duration was some 8 hours. The optimal dose of the drug amounted to 75 mg/day.
Application & Function
1. Lappaconite Hydrobromide has the heart stimulating effect.
2. Lappaconite Hydrobromide owns the function of anti-cancer and anti inflammatory.
3. Lappaconite Hydrobromide is also used in the treatment of rheumatism, intermittent fevers and acute inflammatory infections.
Specification
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