Pharma Lappaconitine Hydrobromide Powder Hydrobromide Lappaconitine API Lappaconitine Hydrobromide

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: D-sung Lappaconitine Hydrobromide
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Adult
• State: Powder
• Purity: >99%
• Product Name: Lappaconitine Hydrobromide
• Name: Lappaconitine Hydrobromide Powder
• Appearance: White or Almost Crystalline Powder
• Grade: Pharmaceutical Grade
• Assay: HPLC 99%
• Application: Analgesic
• Specific: COA
• Test Method: HPLC
• Shelf Life: 2 Years
• CAS No.: 97792-45-5
• Molecular Formula: C32h45brn2o8
• MW: 665.61200
• Melting Point: 223-226 C
• Boiling Point: 740.8 C at 760 Mmhg
• Flash Point: 401.8 C
• Transport Package: Negotiable
• Specification: Negotiable
• Trademark: D-sung
• Origin: Shaanxi Xi′an
• Production Capacity: 5000kg/Month

Product Description

Pharma Lappaconitine Hydrobromide Powder Hydrobromide Lappaconitine API Lappaconitine Hydrobromide

Product Description

 

Product Details

 

Product Name	Lappaconitine hydrobromide
CAS No.	97792-45-5
Purity	99%
MW	665.61200
Appearance and shape	White or almost crystalline powder

Lappaconitine hydrobromide (Lappaconitine) is a diterpene alkaloid isolated from the ranunculaceae plant Lappaconitine -Labaconitine, its chemical name is (1α,14α,16β)-20-B Base-1,14,16Chemicalbook-Trimethoxyaconitine-4,8,9-triol 4-[2-(acetylamino)benzoate hydrobromide monohydrate. It is the first non-addictive analgesic drug in China. It has the effects of analgesia, antipyretic, swelling and local anesthesia, and has no addictive and accumulation effects.

Lappaconitine hydrobromide, a diterpene alkaloid, is a drug for the treatment of cardiac arrhythmias. IC50 value: Target: A natural product for anti-cardiac arrhythmias In vitro: Lappaconitine hydrobromide was found to exert an inhibitory effect on inward tetrodotoxin-sensitive sodium currents without changing their voltage dependence [1]. In vivo: The effect of Lappaconitine hydrobromide on aconitine--induced arrhythmias is due to modulation of genes encoding Na(+)-, K(+)-, Ca(2+)-channels, conducting ionic currents (I(Na), I(to), I(Ks), I(K1), I(CaT)), which are involved in the formation of different phases of the action potential [2]. Lappaconitine hydrobromide was found to be beneficial both in ventricular and supraventricular premature beats. Oral allapinine usually showed its effect 40-60 minutes following its administration, its maximum action being 4-5 hours later, its duration was some 8 hours. The optimal dose of the drug amounted to 75 mg/day.
 

Application & Function

 

 

1. Lappaconite Hydrobromide has the heart stimulating effect.
2. Lappaconite Hydrobromide owns the function of anti-cancer and anti inflammatory.
3. Lappaconite Hydrobromide is also used in the treatment of rheumatism, intermittent fevers and acute inflammatory infections.

Specification