Raw Material CAS 82009-34-5 Cilastatin Pharmaceutical Intermediate Cilastatin Sodium Powder Material Cilastatin

• Powder: Yes
• Customized: Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Powder
• Purity: >99%
• Model NO.: Dsung-Cilastatin
• Product Name: Cilastatin
• Name: Cilastatin Powder
• Appearance: White Powder
• Grade: Pharmaceutical Grade
• Assay: HPLC 99%
• Application: Pharmaceutical Intermediate
• Specific: COA
• Test Method: HPLC
• Shelf Life: 2 Years
• CAS No.: 82009-34-5
• Mf: C16h26n2o5s
• MW: 358.453
• Density: 1.275
• Melting Point: 156-158 C
• Boiling Point: 655.5 C at 760 Mmhg
• Transport Package: Negotiable
• Specification: 99%
• Trademark: D-Sung
• Origin: Shaanxi
• Production Capacity: 500kg/Month

Product Description

Raw Material CAS 82009-34-5 Cilastatin Pharmaceutical Intermediate Cilastatin Sodium Powder Material Cilastatin

 

Product Description

Product Details

Product Name	Cilastatin
CAS No.	82009-34-5
MF	C16H26N2O5S
MW	358.453
Appearance and shape	White powder

The monosodium salt of cilastatin. It is an inhibitor of dehydropeptidase I (membrane dipeptidase, 3.4.13.19), an enzyme found in the brush border of renal tubes and responsible for degrading the antibiotic imipenem. Cilastatin sodium is therefore administ red with imipenem to prolong the antibacterial effect of the latter by preventing its renal metabolism to microbiologically inactive and potentially nephrotoxic products.
Biological ActivityDipeptidase inhibitor (LTDase, leukotriene D4 hydrolase, dehydropeptidase I) that displays a K i value of 0.11 μ M. Inhibits metabolism of LTD 4 to LTE 4 and the hydrolysis of β -lactam antibiotics. Nephroprotective; reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells.

Application & Function

Cilastatin has antibacterial effects on Gram-positive and negative aerobic and anaerobes. The antibacterial spectrum includes Streptococcus, Staphylococcus aureus, Escherichia coli, Klebsiella, some strains of Acinetobacter, Haemophilus bacillus, Proteus, Serratia, Pseudomonas aeruginosa, etc. Clinically, it is mainly used for respiratory tract infections, biliary tract infections, urinary system and abdominal cavity infections, skin and soft tissues, bones and joints, gynecological infections caused by gram-positive bacteria, negative bacteria, and anaerobic bacteria.

Specification