Pharmaceuticals Intermediate Amlodipine Raw Powder Amlodipine Purity Amlodipine
Product Description
Product Details
| Product name |
Amlodipine |
| Cas number |
88150-42-9 |
| Apperance |
White powder |
| MF |
C20H25ClN2O5 |
| MW |
408.8759 |
| Melting point |
178-179ºC |
| Density |
1.227 |
Amlodipine is a long-acting calcium channel blocker.Target: Calcium ChannelAmlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the movement of calcium ions into vascular smooth muscle cells and cardiac muscle cells. Experimental data suggest amlodipine binds to both dihydropyridine and nondihydropyridine binding sites. The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. Amlodipine inhibits calcium ion influx across cell membranes selectively, with a greater effect on vascular smooth muscle cells than on cardiac muscle cells. Negative inotropic effects, or decreased heart muscle contractility, can be detected in vitro, but such effects have not been seen in intact animals at therapeutic doses. Serum calcium concentration is not affected by amlodipine. Within the physiologic pH range, amlodipine is an ionized compound (pKa = 8.6), and its interaction with the calcium channel receptor is characterized by a gradual rate of association and dissociation with the receptor binding site, resulting in a gradual onset of effect. Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure.
Application&Function
1. Dilate the peripheral arterioles to reduce peripheral resistance (post-load), thereby reducing myocardial energy consumption and oxygen demand;
2. Dilate the coronary arteries and coronary arterioles in the normal and ischemic areas to increase myocardial oxygen supply in patients with coronary artery spasm (variant angina).
Specification
Audited Supplier 
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