99% Purity CAS 117704-25-3 Doramectin Veterinary Medicine Doramectin Powder Material Doramectin

• Varieties: Doramectin
• Component: Doramectin
• Type: Doramectin
• Pharmacodynamic Influential Factors: Doramectin
• Storage Method: Room Temperature
• Product Name: Doramectin
• Model NO.: Dsung-Doramectin
• Name: Doramectin Powder
• Appearance: White Crystalline Powder
• Grade: Veterinary Grade
• Assay: HPLC 99%
• Application: Veterinary Medicine
• Specific: COA
• Test Method: HPLC
• Shelf Life: 2 Years
• CAS No.: 117704-25-3
• Molecular Formula: C50h74o14
• MW: 899.11400
• Melting Point: 116 - 119 C
• Boiling Point: 967.4 C at 760 Mmhg
• Density: 1.25 g/cm3
• Transport Package: Negotiable
• Specification: 99%
• Trademark: D-Sung
• Origin: Shaanxi
• Production Capacity: 500kg/Month

Product Description

99% Purity CAS 117704-25-3 Doramectin Veterinary Medicine Doramectin Powder Material Doramectin

 

Product Description

Product Details

Product Name	Doramectin
CAS No.	117704-25-3
Purity	99%
MW	899.11400
Appearance and shape	White crystalline powder

Doramectin is obtained by fermenting a new strain of Streptomyce avermitilis. It is a broad-spectrum antiparasitic drug. It has a good repellent effect on internal and external parasites, especially some nematodes (roundworms) and arthropods, but it is not effective on tapeworms, flukes and protozoa. Its mechanism of action is mainly to increase the release of the inhibitory transmitter γ-aminobutyric acid (GABA) of the worm, thereby blocking the transmission of neural signals, causing muscle cells to lose their ability to contract, and causing the worm to die. The mammalian peripheral neurotransmitter is acetylcholine and is not affected by doramectin. Doramectin does not easily penetrate the blood-brain barrier, has minimal damage to the central nervous system, and is safer for livestock.

Application & Function

It is used for the treatment and control of internal parasitosis (gastrointestinal and pulmonary nematodes), ticks and mange (and other ectoparasites). Doramectin is a derivative of ivermectin. Its spectrum includes:Haemonchus spp., Ostertagia spp.,  Trichostrongylusspp., Cooperia spp., Oesophagostomum spp., Dictyocaulus viviparus, Dermatobia hominis, Boophilus microplus,  Psoroptes bovis, among many other internal and external parasites. It is available in 2 dosage forms: as aninjection and as a 5 mg/ml topical solution.
Doramectin is effective against the major parasitic roundworms: gastrointestinal and pulmonary. It is also effecive against most  mites and lice species, and against numerous myiases (e.g. those caused by screwworm flies, bot flies and warble flies) usually regardless of the delivery form As all macrocyclic lactone doramectin acts as agonist of the GABA (gamma-aminobutyric acid) neurotransmitter in nerve cells and also binds to glutamate-gated chloride channels in nerve and muscle cells of invertebrates. In both cases it blocks the transmission of neuronal signals of the parasites, which are either paralyzed and expelled out of the body, or they starve. It also affects the reproduction of some parasites by diminishing oviposition or inducing an abnormal oogenesis.

Specification