Pharmaceutical Intermediate Entecavir Purity Entecavir Monohydrate Entecavir

• Powder: Yes
• Customized: Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Powder
• Purity: >99%
• Model NO.: D-sung-Entecavir
• Product Name: Entecavir
• Appearance: White Crystal Powder
• Grade: Pharmaceutical Grade
• Assay: HPLC 99%
• Application: Pharmaceutical Intermediate
• Specific: COA
• Test Method: HPLC
• Shelf Life: 2 Years
• CAS No.: 209216-23-9
• Mf: C12h17n5o4
• MW: 295.128
• Density: 1.81
• Melting Point: >220c
• Boiling Point: 661.4 °c at 760 Mmhg
• Refractive Index: 1.837
• Transport Package: Negotiable
• Specification: Negotiable
• Trademark: D-sung
• Origin: Shaanxi Xi′an
• Production Capacity: 5ton/Month

Product Description

Pharmaceutical Intermediate Entecavir Purity Entecavir Monohydrate Entecavir

Product Description

 

Product Details

 

Product Name	Entecavir
Appearance	White crystalline powder
CAS No.	142217-69-4
MF	C12H15N5O3
MW	277.284

Entecavir is an oral antiviral drug used in the treatment of hepatitis B infection.Entecavir is a nucleoside analog (more specifically, a guanosineanalogue) that inhibits reverse transcription, DNA replication and transcription in the viral replication process. It also helps prevent the hepatitis B virus from multiplying and infecting new liver cells.Entecavir is also indicated for the treatment of chronic hepatitis B in adults with HIV/AIDS infection.

Application & Function

 

Function
This product is a nucleoside analogue of guanine, which has inhibitory effect on hepatitis B virus (HBV) polymerase.   It can be converted into active three phosphate by phosphorylation, and the half-life of three phosphate in cells is 15 hours.   The natural substrate and HBV polymerase three phosphate deoxyguanosine competition, entecavir three phosphate can inhibit the viral polymerase (reverse transcriptase) of all three activities:
(1) HBV polymerase promoter;
(2) before the formation of genomic mRNA reverse transcription negative strand synthesis;
(3) HBV DNA is the chain.
Appliction
1.  Entecavir is an oral antiviral drug used in the treatment of hepatitis B infection.
2.  Entecavir is a nucleoside analog (more specifically, a guanosineanalogue) that inhibits reverse transcription, DNA replication and transcription in the viral replication process.   The drug's manufacturer claims that entecavir is more efficacious than previous agents used to treat hepatitis B (lamivudine and adefovir).
3.  It also helps prevent the hepatitis B virus from multiplying and infecting new liver cells.   Entecavir is also indicated for the treatment of chronic hepatitis B in adults with HIV/AIDS infection.
 

Specification