Imipenem Impurity Cilastatin CAS 82009-34-5 99% Purity Raw Powder Cilastatin
Product Description
Product Details
| Product Name |
Cilastatin |
| Appearance |
White powder |
| Purity |
99%min by HPLC |
| CAS No. |
82009-34-5 |
Cilastatin is a pharmaceutical compound that is primarily used in combination with the antibiotic drug imipenem. The combination of cilastatin and imipenem is known as imipenem/cilastatin, and it is used to treat severe bacterial infections.
1.Role in Combination Therapy: Cilastatin is not used as a standalone medication but is combined with imipenem. Cilastatin acts as an inhibitor of the enzyme dehydropeptidase I (DHP-I). By inhibiting DHP-I, cilastatin prevents the breakdown of imipenem in the kidneys, thus increasing the concentration of imipenem in the bloodstream and improving its effectiveness.
2.Spectrum of Activity: The combination of imipenem and cilastatin is broad-spectrum, meaning it is effective against a wide range of bacterial infections. It is particularly useful in treating serious infections caused by multi-drug resistant organisms, such as certain strains of Enterobacteriaceae and Pseudomonas aeruginosa.
3.Clinical Applications: Imipenem/cilastatin is commonly used to treat severe infections, including complicated intra-abdominal infections, complicated urinary tract infections, hospital-acquired pneumonia, and bacterial septicemia. It is also used in empirical therapy when the specific causative organism is not yet identified.
4.Dosage and Administration: The dosage of imipenem/cilastatin can vary depending on the type and severity of the infection, as well as the patient's weight, renal function, and other factors. It is usually administered intravenously (IV) over a specified period, and the dosage and duration of treatment are determined by a healthcare professional.
Specification
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