99% CAS 189954-96-9 Firocoxib Raw Material Firocoxib Powder Veterinary Firocoxib

• Customization: Available
• Varieties: Infectious Disease Prevention Medicine
• Component: Chemical Synthetic Drugs
• Model NO.: D-sung Firocoxib
• Type: The First Class
• Pharmacodynamic Influential Factors: Animal Species
• Storage Method: Normal
• Product Name: Firocoxib
• Name: Firocoxib Powder
• Appearance: White Powder
• Color: White
• Grade: Pharmaceutical Grade
• Assay: HPLC 99%
• Application: Insecticide
• Specific: COA
• Test Method: HPLC
• Shelf Life: 2 Years
• CAS No.: 189954-96-9
• Mf: 78-80°c
• MW: 336.402
• Density: 1.31
• Melting Point: 78-80°c
• Transport Package: Negotiable
• Specification: 99%
• Trademark: D-sung
• Origin: Shaanxi Xi′an
• Production Capacity: 50kg/Month

Product Description

99% CAS 189954-96-9 Firocoxib Raw Material Firocoxib Powder Veterinary Firocoxib

Product Description

Product Details

Product name	Firocoxib
Appearance	White powder
CAS NO.	189954-96-9
MF	78-80°C
MW	336.402

Firocoxib(ML 1785713) is a potent and selective cyclooxygenase (COX)-2 inhibitor with IC50 of 0.13 uM, 58 fold sensitivity for COX2 VSCOX1.IC50 value: 0.13 uM [1]Target: COX2 inhibitorin vitro: Blood concentrations resulting in 50% inhibition of COX-1 and COX-2 activity in vitro were 75 +/- 2 microM and 0.13 +/- 0.03 microM, respectively, and selectivity for inhibiting COX-2 relative to COX-1 was 58. Firocoxib had moderate to high oral bioavailability (54% to 70%), low plasma clearance (4.7 to 5.8 mL/min/kg), and an elimination half-life of 8.7 to 12.2 hours [1]. in vivo: Administration of firocoxib did not cause any adverse effects on GI, or hematological or serum biochemical variables and appears to have been well tolerated by dogs [2]. Firocoxib (0.5 mg/kg) was initially administered i.v. to calves, and following a 14-day washout period, animals received firocoxib orally prior to cautery dehorning. Firocoxib concentrations were determined by liquid chromatography-tandem mass spectrometry [3]. Firocoxib 5 mg/kg was given orally once daily for 180 days to five dogs with clinical signs and histopathological lesions consistent with solar dermatitis/actinic keratosis. On days 0, 50 and 180, the severity of erythema, skin shine, induration and the number of comedones were evaluated by a clinical scoring system [4].

Application&Function

 1. Used for the control of pain and inflammation associated with osteoarthritis and for the control of postoperative pain and inflammation associated with soft-tissue and orthopedic surgery in dogs.
 2. Used for the control of pain and inflammation associated with osteoarthritis.

Specification