Raw Material CAS 59-05-2 Methotrexate Powder Methotrexate 99% Purity Methotrexate

• Powder: Yes
• Customized: Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Powder
• Purity: >98%
• Model NO.: Dsung-Methotrexate
• Product Name: Methotrexate
• Name: Methotrexate Powder
• Appearance: Orange Powder
• Color: Orange Color
• Application: Pharmaceutical Intermediates
• Grade: Pharmaceutical Grade
• Assay: 99%
• Test: HPLC
• Specific: COA
• Shelf Life: 2 Years
• CAS: 59-05-2
• Mf: C20h22n8o5
• MW: 454.43928
• Density: 1.536
• Boiling Point: 561.26 C (Rough Estimate)
• Transport Package: Negotiable
• Specification: HPLC99%
• Trademark: D-Sung
• Origin: Shaanxi
• Production Capacity: 500kg/Month

Product Description

Raw Material CAS 59-05-2 Methotrexate Powder Methotrexate 99%  Purity Methotrexate

Product Description

Product Details

Product Name	Methotrexate
CAS NO.	59-05-2
Purity	99%
Density	1.536
Appearance and shape	Orange powder

Methotrexate is a cell cycle arresting agent with varying effects. Methotrexate arrests the cell cycle in late G1/S-phase, therefore inhibiting the synthesis of DNA, RNA, thymidylates, and proteins. In the previous cases the inhibition of enzymes involved in purine metabolism, leading to accumulation of adenosine, or the suppression of intercellular adhesion molecule expression by T cells as the main mechanism of action by methotrexate. The compound has been observed to irreversibly inhibit dihydrofolate reductase (DHFR) and thymidylate synthetase (TS). Methotrexate has been shown to modulate inflammation by promoting adenosine release or inhibiting transmethylation reactions. In adherent splenic cells, IL-1 production was decreased by methorexate.

Application & Function

Function
1.It is used to treat cancer, autoimmune diseases, ectopic pregnancy, and for medical abortions.
2.It is used for include breast cancer, leukemia, lung cancer, lymphoma, and osteosarcoma.Types of autoimmune diseases
3.It is used for include psoriasis, rheumatoid arthritis, and Crohn's disease.
Application
Methotrexate is used as a disease-modifying treatment for some autoimmune diseases, including rheumatoid arthritis, juvenile dermatomyositis, psoriasis, psoriatic arthritis, lupus, sarcoidosis, Crohn's disease (although a recent review has raised the point that it is fairly underused in Crohn's disease), eczema and many forms of vasculitis. Although originally designed as a chemotherapy drug (using high doses), in low doses, methotrexate is a generally safe and well tolerated drug in the treatment of certain autoimmune diseases.

Specification