| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
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| Product Name | Capecitabine |
| Appearance | white to off-white powder |
| CAS No. | 154361-50-9 |
| MF | C15H22FN3O6 |
| MW | 359.35 |
Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers.Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue.
Capecitabine is rapidly absorbed by the intestinal mucosa after oral administration, and then converted into an inactive intermediate 5'-deoxy-5' fluorocytidine in the liver by carboxyl esterase, followed by cytidine removal from liver and tumor tissues.The action of the aminoase is converted to 5'-deoxy-5' fluorouridine and finally catalyzed by thymidine phosphorylase to fluorouracil (5-FU) in tumor tissues. Clinical studies have shown that the concentration of 5-FU in tumor tissue after oral administration is significantly higher than that of blood and muscle. The efficacy of tumors in a variety of animals was significantly higher than 5-FU.
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