| Customization: | Available |
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| Powder: | Yes |
| Customized: | Customized |
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| Product Name | Pirfenidone |
| Melting point | 96-97ºC |
| Density | 1.1±0.1 g/cm3 |
| CAS No. | 53179-13-8 |
| Boiling point | 329.1ºC |
Pirfenidone (PFD) is a new pyridone compound with a broad-spectrum anti-fibrosis effect, which can prevent and reverse the formation of fibrosis and scars; it was marketed by Shiono Yoshihide in 2008 and has been obtained. Approved by the U.S. Food and Drug Administration, it is the first drug that has proven to have a Chemicalbook effect on idiopathic pulmonary fibrosis (IPF) through a repeated, randomized, placebo-controlled Phase III clinical trial; and the drug is in the renal interstitium Fibrosis, liver fibrosis and other fibrotic diseases are also effective; at the same time, it is also effective in kidney disease (focal segmental glomerulosclerosis), hypertrophic cardiomyopathy, adult type I multiple neurofibroma, and adolescents. Type I multiple neurofibroma and plexiform neurofibroma, diabetes with kidney disease, phase II clinical studies of uterine leiomyoma have been widely used.
1.Pirfenidone is used to treat a lung disease called idiopathic pulmonary fibrosis (IPF). IPF causes scar tissue to form deep within your lungs. The scar tissue thickens and becomes stiff or thick over time, which can make it harder for your lungs to work. Decreased lung function can make it hard for you to breathe. Other medical problems can occur when your brain, heart, and other organs do not get enough oxygen.
2.pirfenidone can inhibit the uterine flesh tumour cells and leiomyoma cells proliferation. Pirfenidone can inhibit the TGF - beta - 1 inducing fibroblast collagen formation. Inhibition of PD.GF, FGF and TGF - beta - 1 inducing fibroblast proliferation. In hamster model, pirfenidone, taken by mouth, that can the prevention and treatment of pulmonary fibrosis induced by bleomycin.
3.Pirfenidone is an anti-fibrotic drug for the treatment of idiopathic pulmonary fibrosis (IPF). It works by reducing lung fibrosis through downregulation of the production of growth factors and procollagens I and II.
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