Raw Material Alectinib HCl Pharmaceutical Intermediate Alectinib Hydrochloride Powder Alectinib

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: Dsung-Alectinib
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Powder
• Purity: >98%
• Product Name: Alectinib
• Name: Alectinib Powder
• Appearance: White Crystalline Powder
• Grade: Pharmaceutical Grade
• Assay: HPLC 99%
• Application: Pharmaceutical Intermediate
• Specific: COA
• Test Method: HPLC
• Shelf Life: 2 Years
• CAS No.: 1256580-46-7
• Mf: C30h34n4o2
• MW: 482.628
• Einecs No.: 821-541-6
• Density: 1.28
• Boiling Point: 722.5+-60.0 C(Predicted)
• Transport Package: Negotiable
• Specification: 99%
• Trademark: D-Sung
• Origin: Shaanxi
• Production Capacity: 500kg/Month

Product Description

Raw Material Alectinib Hcl Pharmaceutical Intermediate Alectinib Hydrochloride Powder Alectinib

 

Product Description

Product Details

Product Name	Alectinib
CAS No.	1256580-46-7
MF	C30H34N4O2
MW	482.628
Appearance and shape	White Crystalline Powder

Alectinib hydrochloride, developed by Chugai Pharmaceutical/ Hoffman-La Roche under the trade name Alecensa, was approved in Japan in April 2014 for the treatment of anaplastic lymphoma kinase (ALK) fusion-gene positive, unresectable, advanced, or recurrent non-small cell lung cancer (NSCLC).    The compound is a highly selective second-generation ALK inhibitor, and while alectinib currently remains a focus of further development in Europe and the U.S., the compound has been granted orphan drug designation in Japan after showing a 93.5% objective response rate in phase II clinical trials.    In addition to providing rapid treatment response time in a majority of patients, trials showed a 76% 2-year progression-free survival rate.    Since the initial approval of crizotinib-the first ALK inhibitor indicated for treatment of ALKrearranged NSCLC -patients treated with crizotinib have shown remarkable improvement as compared to treatment with other chemotherapeutic methods,21 although drug resistance has shown to be a major side effect of this therapy.    Preliminary preclinical and clinical studies of alectinib have shown significant promise for overcoming drug resistance developed with other ALK inhibitors.
Alectinib hydrochloride is a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth.    Also is an intermediate of Alectinib (C183360), a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth.

Application & Function

Alectinib is an orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity.    Upon administration, alectinib binds to and inhibits ALK kinase, ALK fusion proteins as well as the gatekeeper mutation ALKL1196M known as one of the mechanisms of acquired resistance to small-molecule kinase inhibitors.    The inhibition leads to disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-overexpressing tumor cells.

Specification