Pharmaceutical Intermediate Penciclovir Powder Raw Material Penciclovir Powder Penciclovir

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: D-sung Penciclovir
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Solid
• Purity: >99%
• Shelf Life: 2 Years
• Mf: C10h15n5o3
• MW: 253.262
• Density: 1.68
• Melting Point: 275-277°c
• Boiling Point: 653.4 °c at 760 Mmhg
• Refractive Index: 1.748
• Flash Point: 348.9 °c
• Psa: 130.05000
• Logp: -0.72610
• Safety Instructions: 26
• Hazard Category Code: 36
• Rtecs: Up0789400
• Dangerous Goods Transport Code: Un 1993 3/Pg 3
• Hazard Category: 3.2
• Transport Package: Negotiable
• Specification: 99%
• Trademark: D-sung
• Origin: Shaanxi Xi′an
• Production Capacity: 500kg/Month

Product Description

Pharmaceutical Intermediate Penciclovir powder Raw Material Penciclovir powder Penciclovir

Product Description

Product Details

Product name	Penciclovir
CAS	39809-25-1
Appearance	white powder
Assay	99%

Penciclovir, is a white crystalline solid chemical with the chemical formula 9-[4-hydroxy-3-(hydroxymethyl)-butyl]-guanine , molecular formula C10H15N5O3, molecular weight 253.25800. soluble in dimethyl sulfoxide, slightly soluble in water, very slightly soluble in ethanol, insoluble in methanol, chloroform or ethyl acetate; slightly soluble in Slightly soluble in 0.1 mol/L hydrochloric acid solution or 0.1 mol/L sodium hydroxide solution, melting point 275~277ºC. Penciclovir is mainly used clinically for herpes simplex and genital herpes on the mouth, lips or face.

Application&Function

 

Application
DescriptionVectavir was launched in the UK for herpes labialis. Penciclovir is synthetically available by two routes of four steps each from 2- (hydroxymethyl)butane-l,4-diol and is active against HSV-1, HSV-2 VZV but has limited activity against CMV. Vectavir is an acyclic guanosine analog that acts as a competitive inhibitor of DNA polymerase. It is a metabolic product of famcyclovir that is preferentially phosphorylated by viral infected cells (by thymidine kinases) over normal cells. The triphosphate has a low activity against cellular DNA polymerase which is one possible explanation for its low toxicity. While its spectrum of activity is similar to acyclovir, it is longer acting because its triphosphate is 20 times more stable and is not metabolized.

Specification