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Product Name | Astragaloside |
Appearance | White Powder |
CAS No. | 83207-58-3 |
MF | C41h68o14 |
MW | 784.97000 |
Astragaloside IV, also known as Astragaloside IV, is a natural saponin compound isolated and extracted from the legume plant Astragalus membranaceus. It is the main monomeric active substance in Astragalus membranaceus and the main material basis for its pharmacological effects. Huangqi is a leguminous plant and a perennial herbaceous plant. It is cold resistant, drought tolerant, heat sensitive, and flood resistant, and mostly grows in dry sunny mountain slopes, grasslands, or shrubs on sunny forest edges. Cultivation is suitable in a cool and dry climate, with sandy soil with good drainage and deep soil layers being preferred. Astragalus membranaceus is a commonly used Chinese medicine with warm nature and sweet taste. It has the functions of tonifying qi and consolidating the surface, diuresis and detoxification, discharging pus, and astringing sores and muscles. It is used for qi deficiency and fatigue, eating less and loose stools, sinking of middle qi, chronic anal discharge, bloody stool, metrorrhagia, surface deficiency and spontaneous sweating, qi deficiency and edema, chronic nephritis, albuminuria, diabetes and other diseases. Modern pharmacological research has shown that Astragalus membranaceus has the effects of enhancing the body's immune function, strengthening the heart and lowering blood pressure, lowering blood sugar, diuresis, anti-aging, and anti fatigue. The main active ingredient in Huangqi is Huangqi polysaccharide
Huangqi glycoside A is an isomer of Huangqi glycoside IV. Astragaloside IV has protective effects on cardiovascular, immune, digestive, and nervous systems.
1. Astragaloside IV can inhibit oxidative stress, reduce cellular reactive oxygen species (ROS) levels, enhance antioxidant defense systems, increase anti apoptotic and anti-inflammatory pathways, and regulate T cell differentiation and infiltration in the central nervous system. This indicates that Astragaloside IV may be used clinically for the treatment and prevention of MS. In short, Astragaloside IV can play a certain role in various diseases by regulating the immune function of the body.
2. Astragaloside IV has a protective effect on brain injury, lung injury, kidney injury, and heart injury caused by ischemia-reperfusion.
3. Astragaloside IV not only has a protective effect on myocardial injury caused by ischemia and hypoxia, but also has certain effects on myocardial hypertrophy, myocarditis, myocardial fibrosis, etc.
4. Astragaloside IV has anti-inflammatory activity, which in turn has effects on pneumonia, airway inflammation, asthma, acute pancreatitis, and other conditions.
5. Huangqi IV glycoside exerts an anti CVB3 virus effect by upregulating the expression of IFN - γ at the mRNA level.
6. Huangqi Glycoside IV induces TNF - α secretion in 3T3-L1 adipocytes by inhibiting the activity of hepatic glycogen phosphorylase (GP) and glucose-6-phosphatase (G6Pase), improving resistance and exerting a hypoglycemic effect.
7. Astragaloside A has certain inhibitory effect on lung cancer, liver cancer, breast cancer and gastric cancer in vitro.